Nadim · Golowasch · Bucher

Welcome to the STG lab!

Our laboratory is part of the Federated Department of Biological Sciences of the New Jersey Institute of Technology (NJIT) and Rutgers University Newark. It is run by three Principal Investigators, Farzan Nadim, Jorge Golowasch, and Dirk Bucher, all faculty in the department. We use both experimental and theoretical approaches to study the neurophysiology of a small central pattern generating circuit in lobsters and crabs, the stomatogastric ganglion (STG). Central pattern generators (CPGs) are networks of nerve cells in the central nervous system that generate the basic patterned electrical activity underlying most rhythmic behaviors like walking and breathing in all animals. We are taking advantage of the experimental accessibility of the crustacean nervous system to uncover fundamental principles that govern neural processing across all animal and human nervous systems.

  • STG neurons3D reconstructions of confocal images
  • Central Pattern GenerationThe pyloric circuit and the rhythm it produces
  • Decapod CrustaceansJonah crab and Maine lobster, our experimental animals
  • Neuropil structure of the STGCrab (l, m) and lobster (r) STGs. Stained synaptic contacts are shown in red.
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News

Lab Members

Michael Gray, Ph.D. accepted a postdoc position at the University of Missouri. He will join David Schulz's lab to study mouse spinal neurons. Congratulations!

Supriya Kannan joined the lab to do her Master's thesis. She will study the effect of peptide neuromodulators on spike synchrony in electrically coupled neurons. Welcome!

Deana Mustafa and Angeles Vivanca are our new lab technicians. Welcome!

Latest Publications

Nelly Daur, Farzan Nadim, and Dirk Bucher published a review paper on the stomatogastric nervous system in Current Opinion in Neurobiology:

Daur N, Nadim F and Bucher D (2016) The complexity of small circuits: the stomatogastric nervous system. Curr Opin Neurobiol 41:1-7.   Journal  

Xinping Li and Farzan Nadim, together with the Rotstein lab in the NJIT Math Department, published a paper in the Journal of Neurophysiology on how membrane resonance properties and electrical coupling affect network frequency:

Chen Y, Li X, Rotstein HG and Nadim F (2016) Membrane potential resonance frequency directly influences network frequency through electrical coupling. J Neurophysiol doi: 10.1152/jn.00361.2016. [Epub ahead of print].   PubMed  

Farzan Nadim published a theory paper on network modulation in the Journal of Computational Neuroscience, with collaborators Nick Kintos (Saint Peter's) and Mike Nusbaum (UPenn):

Kintos N, Nusbaum MP, and Nadim F (2016) Convergent neuromodulation onto a network neuron can have divergent effects at the network level. J Comput Neurosci 40(2):113-135.   PubMed  

Michael Gray and Jorge Golowasch published a paper on how the voltage-dependence of a modulator-activated current is regulated by intracellular signaling pathways activated by extracellular calcium:

Gray M and Golowasch J (2016) Voltage dependence of a neuromodulator-activated ionic current. eNeuro doi: 10.1523/ENEURO.0038-16.2016.   PubMed  

Dirk Bucher published a chapter on axon physiology in a book edited by Kathleen Rockland:

Bucher D (2015) Contribution of axons to short-term dynamics of neuronal communication. In: Axons and Brain Architecture (Rockland KS, ed). Elsevier, Boston  Google books